{"id":8884,"date":"2025-03-14T08:00:00","date_gmt":"2025-03-14T08:00:00","guid":{"rendered":"https:\/\/www.raziemah.com\/blog\/?p=8884"},"modified":"2024-12-14T21:23:08","modified_gmt":"2024-12-14T21:23:08","slug":"looking-at-alexei-sharov-and-morten-tonnessens-chapter-2021-composite-agency-part-4-of-5","status":"publish","type":"post","link":"https:\/\/www.raziemah.com\/blog\/?p=8884","title":{"rendered":"Looking at Alexei Sharov and Morten Tonnessen&#8217;s Chapter (2021) &#8220;Composite Agency&#8221; (Part 4 of 5)"},"content":{"rendered":"\n<p>0515 Here is a list of benefits for subagents, including a cell-surface receptor and the contractile vacuole in paramecium.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide164.png\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide164.png\" alt=\"\" class=\"wp-image-8885\" srcset=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide164.png 600w, https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide164-300x200.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/figure>\n\n\n\n<p>0516 Surely, this list serves as criteria for models of the specificative and exemplar sign-interpretants (SI<sub>s<\/sub>&nbsp;and SI<sub>e<\/sub>).<\/p>\n\n\n\n<p>0517 Section 10.4 discusses how subagents find ways to guide one another.&nbsp;&nbsp;The configuration of a stimulus response comes to mind, where one sub-agent provides a signal<sub>2a<\/sub>&nbsp;(a real-initiating event<sub>2a<\/sub>) that provides information<sub>2b<\/sub>&nbsp;for another subagent.<\/p>\n\n\n\n<p>This is precisely what happens in the recent example.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide165.png\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide165.png\" alt=\"\" class=\"wp-image-8886\" srcset=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide165.png 600w, https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide165-300x200.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/figure>\n\n\n\n<p>0518 Indeed, I might imagine that a feedback loop might be established where the contractile vacuole, in its goal (SO<sub>e<\/sub>), signals to the cell-surface agent (SV<sub>s<\/sub>) to become less sensitive to nicotine.<\/p>\n\n\n\n<p>0519 Is that how addiction works?<\/p>\n\n\n\n<p>An ingested chemical that seems to meet a goal, for certain subagents, at first, later becomes less and less effective in meeting that goal, because of downregulation of sensitivity.<\/p>\n\n\n\n<p>0520 Who knows?<\/p>\n\n\n\n<p>The author spends a good deal of effort on discussing how viruses may trick subagents, just like one subagent may trick another, but not for long.&nbsp;&nbsp;There are as many avenues to death as there are subagents.&nbsp;&nbsp;The lesson is sobering.<\/p>\n\n\n\n<p>0521 So, consider the following figure.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide166.png\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide166.png\" alt=\"\" class=\"wp-image-8887\" srcset=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide166.png 600w, https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide166-300x200.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/figure>\n\n\n\n<p>What is that dotted line?<\/p>\n\n\n\n<p>The goal of the cell-surface sub-agent (SO<sub>e<\/sub>) is to somehow send a message to the contractile vacuole (SV<sub>s<\/sub>).<\/p>\n\n\n\n<p>The dotted line is that inter-action.<\/p>\n\n\n\n<p>0522 What is to prevent the cell-surface subagent from continually activating the contractile vacuole?<\/p>\n\n\n\n<p>Well, death by exhaustion from continual spasms is one option.<\/p>\n\n\n\n<p>The other option is that the contractile vacuole secretes something that alters the sensitivity of that particular cell-surface sub-agent.&nbsp;&nbsp;If it so happens that the secretion also lowers the sensitivity of all cell-surface sub-agents, then that is a danger that the paramecium will have to&#8230; um&#8230; live with.<\/p>\n\n\n\n<p>0523 That brings me back to the water fountain business.<\/p>\n\n\n\n<p>One never quite knows whether signaling systems, once established, can morph into absolutely hilarious moments that appear to reduce productivity.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide167.png\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide167.png\" alt=\"\" class=\"wp-image-8888\" srcset=\"https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide167.png 600w, https:\/\/www.raziemah.com\/blog\/wp-content\/uploads\/2024\/12\/Slide167-300x200.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/figure>\n\n\n\n<p>0524 So, my boss, the macronuclear type, waits for the right opportunity to establish a feedback system.<\/p>\n\n\n\n<p>But, because everyone uses the water fountain, there only seems to be impediments.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>0515 Here is a list of benefits for subagents, including a cell-surface receptor and the contractile vacuole in paramecium. 0516 Surely, this list serves as criteria for models of the specificative and exemplar sign-interpretants (SIs&nbsp;and SIe). 0517 Section 10.4 discusses how subagents find ways to guide one another.&nbsp;&nbsp;The configuration of a stimulus response comes to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[417],"tags":[],"class_list":["post-8884","post","type-post","status-publish","format-standard","hentry","category-book-review"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Looking at Alexei Sharov and Morten Tonnessen&#039;s Chapter (2021) &quot;Composite Agency&quot; 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